Marvel Studios’ “Avengers: Endgame” is arguably the most anticipated superhero movie of all time. The film reunites the original six Avengers: Robert Downey Jr. as Iron Man, Chris Evans as Captain America, Mark Ruffalo as Bruce Banner, Chris Hemsworth as Thor, Scarlett Johansson as Black Widow, and Jeremy Renner as Hawkeye. It also makes some room for Brie Larson as Captain Marvel, Paul Rudd as Ant-Man, Don Cheadle as War Machine, Karen Gillan as Nebula, Danai Gurira as Okoye, and Bradley Cooper as Rocket. Together they try to undo what Thanos did at the end of ‘Infinity War.’

Now that the movie has officially opened in theaters, it’s time to start keeping an eye on how it’s doing at the box office. ‘Endgame’ opened Wednesday in some international markets. In one-day it earned $107.5 million in China. Since then it has opened in more markets with an estimated haul of $169M so far. If we see a four-day performance of $300M in China alone, that’s a good sign that the entire global four-day opening for ‘Endgame’ could pass $800M, well past ‘Infinity Wars’ $680M opening weekend total.

Domestically, the Thursday night previews have reportedly collected $43M so far with showtimes starting at 6pm ET. That also beats ‘Infinity War,’ which opened with $39M last year. The goal of beating the “Star Wars: The Force Awakens” preview total of $57 million may be in reach, but it will be a close call.

The first 21 Marvel Movies, starting with “Iron Man” and running through “Captain Marvel,” have already earned a collective total of $19 billion at the worldwide box office. Of all the directors on those films, the ones with the most credits are the Russo brothers, Anthony and Joe. Endgame marks their fourth film in the Marvel Cinematic Universe, the first being “Captain America: The Winter Solder” which is credited with changing the mold for superhero action and giving Steve Rogers, aka Captain America, a character update that set in motion a big change that manifests itself in amazing style in ‘Endgame.’

The Russo Brother’s movies had record-breaking commercial success and critical acclaim all while holding true to their story-driven, character focused films.

“Anthony and Joe Russo are true visionaries,” says Marvel Studios President Kevin Feige. “They are bold filmmakers who have immaculate taste and are not afraid to push the boundaries of what an audience is expecting from films like this. You saw it in ‘Civil War.’ You saw it in ‘The Winter Soldier,’ certainly in ‘Infinity War,’ and now with ‘Endgame,’ which I believe is their master work.”

Continuing, Feige adds, “They’re artistic storytellers who understand how to fulfill and subvert audience expectations in ways that are exceedingly risky. They had the foresight and vision to end ‘Infinity War’ with the heroes losing in such a way that it captured the global imagination and incited a cultural event.”

That cultural event has now culminated in ‘Endgame.’ What is your guess for the final worldwide box office total? Will it surpass “Avatar” and its $2.78 billion? The key word there is repeatability. If fans keep going back to see ‘Endgame’ again and again, it just might get there.

If you’ve seen “Avengers: Endgame” already we’d love to get your spoiler-free reaction in the comments. Remember Captain America says Don’t Spoil “Avengers: Endgame.”

Hat tip to Deadline for help with the early box office numbers from their sources.